Medical Background Research

Unified Risk Bacteria Summary

Bacteria

Associated Condition

Probiotic/Prebiotic Strategies

Key References

Actinobacteriota Radiation Reduce: Animal fat and processed food; Increase fiber and polyphenols Zhao L et al., Nat Rev Gastroenterol Hepatol. 2022; Louis P et al., 2014
Peptostreptococcaceae Radiation Reduce: Processed foods; Fiber-based prebiotics to reduce inflammation Schirmer M et al., Cell Host Microbe. 2016; Lin A et al., Gut Microbes. 2023
Ruminococcaceae Radiation Depends on context; Support diversity with prebiotics, monitor abundance Morrison DJ & Preston T, J Nutr. 2016; Louis P et al., 2014
Lactobacillales Chemotherapy Limit simple sugars; Cautious probiotic use (e.g., L. rhamnosus GG) McFarland LV, Clin Infect Dis. 2015; Kleerebezem M et al., Nat Rev Microbiol. 2019
Intestinimonas butyriciproducens Chemotherapy Reduce: High-protein/fat diet; Increase fiber, no probiotic available Rosario G et al., PMID: 39638782, 2024
Ruminiclostridium spp Chemotherapy Limit refined carbs, increase microbiome diversity through diet Rosario G et al., PMID: 39638782, 2024
Ruminococcus spp Chemotherapy Avoid dysbiotic overgrowth via balanced diet; no direct probiotic Rosario G et al., PMID: 39638782, 2024
Dielma fastidiosa Chemotherapy Not well-characterized; fiber and polyphenol modulation may help Rosario G et al., PMID: 39638782, 2024
Anaerotignum propionicum Chemotherapy Limited evidence; consider anti-inflammatory dietary pattern Rosario G et al., PMID: 39638782, 2024

Unified Protective Bacteria Summary

Bacteria

Associated Condition

Probiotic/Prebiotic Strategies

Key References

Bifidobacterium Radiation Prebiotics: GOS, inulin; Probiotics: B. longum, B. breve, B. infantis Ouwehand AC et al., J Nutr. 2002; Allen SJ et al., Cochrane 2004
Faecalibacterium Chemotherapy Prebiotics: Resistant starch, inulin, arabinoxylans; Probiotics: Synbiotics with Bifidobacteria Miquel S et al., Front Microbiol. 2013; Louis P et al., Nat Rev Gastroenterol Hepatol. 2014
Lachnospiraceae FL020 Chemotherapy Prebiotics: Fiber-rich diet (whole grains, legumes); Probiotics: SCFA-supporting strains Ríos-Covián D et al., Front Microbiol. 2016; Kovatcheva-Datchary P et al., Cell Metab. 2015
Lachnospira Chemotherapy Prebiotics: Inulin-type fructans, psyllium; Probiotics: Experimental support Slavin J, Nutrients. 2013; Scott KP et al., Gut Microbes. 2013
UCG005 Chemotherapy Prebiotics: Whole plant foods (polyphenols, fiber); Probiotics: Diversity boosters Zhao L et al., Nat Rev Gastroenterol Hepatol. 2022; Sonnenburg JL, Cell Metab. 2019
Bacteroidetes Immunotherapy (ICI) Prebiotics: Polyphenols (e.g., green tea, berries), pectin, whole grains; Probiotics: Diet-driven Vetizou M et al., Science. 2015; Chaput N et al., Nat Commun. 2017
Bacteroidaceae Immunotherapy (ICI) Prebiotics: High-fiber diet (inulin, pectin); Probiotics: No direct strain, supported by resistant starch Frank DN et al., PLoS Biol. 2007; Gopalakrishnan V et al., Science. 2018
Rikenellaceae Immunotherapy (ICI) Prebiotics: Mediterranean diet, legumes, fiber; Probiotics: Not commercially available Zitvogel L et al., Nat Rev Immunol. 2018; Routy B et al., Science. 2018
Barnesiellaceae Immunotherapy (ICI) Prebiotics: Polyphenol-rich foods (nuts, cocoa, apples); Probiotics: Rare, in fermented foods Matson V et al., Science. 2018; Davar D et al., Science. 2021